TRIB3 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TRIB3.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human TRIB3.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
The TRIB3 polyclonal antibody (Cat # PAB4034) is used in Western blot to detect TRIB3 in Jurkat cell lysate.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human breast cancer tissue reacted with TRIB3 polyclonal antibody (Cat # PAB4034) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.Enzyme-linked Immunoabsorbent Assay
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Gene Info — TRIB3
Entrez GeneID
57761Protein Accession#
Q96RU7Gene Name
TRIB3
Gene Alias
C20orf97, NIPK, SINK, SKIP3, TRB3
Gene Description
tribbles homolog 3 (Drosophila)
Omim ID
607898Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. [provided by RefSeq
Other Designations
neuronal cell death inducible putative kinase|p65-interacting inhibitor of NF-kappaB|tribbles 3
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Interactome
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Disease
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Publication Reference
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TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver.
Du K, Herzig S, Kulkarni RN, Montminy M.
Science 2003 Jun; 300(5625):1574.
Application:IP, WB-Ti, Human, Mouse, HepG2 cells, Liver.
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SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia.
Bowers AJ, Scully S, Boylan JF.
Oncogene 2003 May; 22(18):2823.
Application:WB-Tr, Human, HT-29, PC-3, U-2 OS cells.
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SINK is a p65-interacting negative regulator of NF-kappaB-dependent transcription.
Wu M, Xu LG, Zhai Z, Shu HB.
The Journal of Biological Chemistry 2003 May; 278(29):27072.
Application:WB-Tr, Human, HEK 293 cells.
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TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver.
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