TXK polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TXK.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human TXK.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-100)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of TXK polyclonal antibody (Cat # PAB3442) in Jurkat cell lysate. TXK (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with TXK polyclonal antibody (Cat # PAB3442) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma. -
Gene Info — TXK
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Interactome
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Pathway
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Disease
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Publication Reference
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Txk, a member of nonreceptor tyrosine kinase of Tec family, acts as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription.
Takeba Y, Nagafuchi H, Takeno M, Kashiwakura J, Suzuki N.
Journal of Immunology 2002 Mar; 168(5):2365.
Application:WB-Tr, Human, Jurkat cells.
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A YAC contig spanning a cluster of human type III receptor protein tyrosine kinase genes (PDGFRA-KIT-KDR) in chromosome segment 4q12.
Spritz RA, Strunk KM, Lee ST, Lu-Kuo JM, Ward DC, Le Paslier D, Altherr MR, Dorman TE, Moir DT.
Genomics 1994 Jul; 22(2):431.
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TXK, a novel human tyrosine kinase expressed in T cells shares sequence identity with Tec family kinases and maps to 4p12.
Haire RN, Ohta Y, Lewis JE, Fu SM, Kroisel P, Litman GW.
Human Molecular Genetics 1994 Jun; 3(6):897.
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Txk, a member of nonreceptor tyrosine kinase of Tec family, acts as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription.
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