TMPRSS2 polyclonal antibody
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More Files
- More Functions
Western Blot (Transfected lysate)
Western blot analysis of control (vector only transfected HEK293T lysate) and TMPRSS2 over-expression lysate (Co-expressed with a C-terminalmyc-DDK tag (~3.1 kDa) in mammalian HEK293T cells).
Immunohistochemistry
Immunohistochemical staining of human rectum shows moderate membranous positivity in glandular cells.
Immunohistochemistry
Immunohistochemical staining of human cerebral cortex shows no positivity in neurons as expected.
Immunohistochemistry
Immunohistochemical staining of human prostate shows strong membranous positivity in glandular cells.
Immunohistochemistry
Immunohistochemical staining of human skeletal muscle shows no positivity in myocytes as expected.
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant human TMPRSS2.
Sequence
GSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKT
Host
Rabbit
Reactivity
Human
Specificity
This antibody reacts to TMPRSS2.
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:200 - 1:500)
Western Blot (0.04-0.4 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western blot analysis of control (vector only transfected HEK293T lysate) and TMPRSS2 over-expression lysate (Co-expressed with a C-terminalmyc-DDK tag (~3.1 kDa) in mammalian HEK293T cells).Immunohistochemistry
Immunohistochemical staining of human rectum shows moderate membranous positivity in glandular cells.Immunohistochemistry
Immunohistochemical staining of human cerebral cortex shows no positivity in neurons as expected.Immunohistochemistry
Immunohistochemical staining of human prostate shows strong membranous positivity in glandular cells.Immunohistochemistry
Immunohistochemical staining of human skeletal muscle shows no positivity in myocytes as expected. -
Gene Info — TMPRSS2
Entrez GeneID
7113Gene Name
TMPRSS2
Gene Alias
FLJ41954, PP9284, PRSS10
Gene Description
transmembrane protease, serine 2
Omim ID
602060Gene Ontology
HyperlinkGene Summary
This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
epitheliasin
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Interactome
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Disease
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