CCNH (phospho T315) polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human brain (left). Negative control was pre-absorbed by immunogen peptide (right).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of human CCNH (phospho T315).
Immunogen
A synthetic peptide corresponding to amino acids 250-330 of human CCNH (phospho T315).
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody detects endogenous levels of Cyclin H protein only when phosphorylated at T315.
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
ELISA (1:10000)
Immunohistochemistry (1:100-300)
Western Blot (1:500-2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (50% glycerol, 0.5% BSA and 0.02% sodium azide).
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human brain (left). Negative control was pre-absorbed by immunogen peptide (right).Enzyme-linked Immunoabsorbent Assay
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Gene Info — CCNH
Entrez GeneID
902Protein Accession#
P51946Gene Name
CCNH
Gene Alias
CAK, p34, p37
Gene Description
cyclin H
Omim ID
601953Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery. [provided by RefSeq
Other Designations
CDK-activating kinase|MO15-associated protein|cyclin-dependent kinase-activating kinase
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Interactome
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Pathway
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Disease
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