EXOSC6 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of human EXOSC6.
Immunogen
A synthetic peptide corresponding to N-terminus of human EXOSC6.
Sequence
MPGDHRRIRGPEESQPPQLYAADEEEAPGTRDPTRLRPVYARAGLLSQAK
Host
Rabbit
Theoretical MW (kDa)
30
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (4-8 ug/mL)
Western Blot (5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (2% sucrose, 0.09% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western Blot analysis of Jurkat cell lysate with EXOSC6 polyclonal antibody (Cat # PAB30060) at 5 ug/mL working concentration.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human muscle (A) and human liver (B) with EXOSC6 polyclonal antibody (Cat # PAB30060) at 4-8 ug/mL working concentration. -
Gene Info — EXOSC6
Entrez GeneID
118460GeneBank Accession#
NM_058219Protein Accession#
NP_478126;Q5RKV6Gene Name
EXOSC6
Gene Alias
EAP4, MTR3, Mtr3p, hMtr3p, p11
Gene Description
exosome component 6
Omim ID
606490Gene Ontology
HyperlinkGene Summary
This gene product constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation. [provided by RefSeq
Other Designations
Mtr3 (mRNA transport regulator 3)-homolog|OTTHUMP00000174902|homolog of yeast mRNA transport regulator 3
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Interactome
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Pathway
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