ADD3 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of human ADD3.
Immunogen
A synthetic peptide corresponding to internal region of human ADD3.
Sequence
AYYDYQGSLEEQEERIQLQKVLGPSCKVLVLRNHGVVALGETLEEAFHYI
Host
Rabbit
Theoretical MW (kDa)
78
Reactivity
Human, Mouse
Form
Liquid
Purification
Affinity purification
Recommend Usage
Immunofluorescence (1:500)
Western Blot (0.2-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (2% sucrose, 0.09% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western Blot analysis of PANC-1 cell lysate with ADD3 polyclonal antibody (Cat # PAB29943) at 0.2-1 ug/mL working concentration.Immunofluorescence
Immunofluorescent staining of mouse HEI-OCI auditory cells with ADD3 polyclonal antibody (Cat # PAB29943) at 1:500 dilution. -
Gene Info — ADD3
Entrez GeneID
120GeneBank Accession#
NM_016824Protein Accession#
NP_058432;Q9UEY8Gene Name
ADD3
Gene Alias
ADDL
Gene Description
adducin 3 (gamma)
Omim ID
601568Gene Ontology
HyperlinkGene Summary
Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced adducin gamma transcripts encoding different isoforms have been described. The functions of the different isoforms are not known. [provided by RefSeq
Other Designations
OTTHUMP00000020463|OTTHUMP00000020464|adducin-like protein 70
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