NCOA1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of NCOA1.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human NCOA1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Ammonium sulfate precipitation
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western blot analysis of SRC1 (arrow) using rabbit NCOA1 polyclonal antibody (Cat # PAB2970). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the NCOA1 gene (Lane 2) (Origene Technologies). -
Gene Info — NCOA1
Entrez GeneID
8648Protein Accession#
NP_003734;Q15788Gene Name
NCOA1
Gene Alias
F-SRC-1, KAT13A, MGC129719, MGC129720, NCoA-1, RIP160, SRC-1, SRC1, bHLHe42, bHLHe74
Gene Description
nuclear receptor coactivator 1
Omim ID
602691Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq
Other Designations
Hin-2 protein|OTTHUMP00000155183|PAX3/NCOA1 fusion protein|steroid receptor coactivator-1
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Interactome
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Disease
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Publication Reference
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Functional characterization of the native NH2-terminal transactivation domain of the human androgen receptor: binding kinetics for interactions with TFIIF and SRC-1a.
Lavery DN, McEwan IJ.
Biochemistry 2008 Mar; 47(11):3352.
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In vitro fluorescence anisotropy analysis of the interaction of full-length SRC1a with estrogen receptors alpha and beta supports an active displacement model for coregulator utilization.
Wang S, Zhang C, Nordeen SK, Shapiro DJ.
The Journal of Biological Chemistry 2007 Feb; 282(5):2765.
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Functional characterization of the native NH2-terminal transactivation domain of the human androgen receptor: binding kinetics for interactions with TFIIF and SRC-1a.
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