TGFBR2 (phospho S225/S250) polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of human TGFBR2.
Immunogen
Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S225/S250 of human TGFBR2.
Host
Rabbit
Theoretical MW (kDa)
64
Reactivity
Human
Specificity
TGFBR2 (phospho S225/S250) polyclonal antibody detects endogenous levels of human TGFBR2 only when phosphorylated at serine 225/250.
Form
Liquid
Purification
Affinity Chromatography
Recommend Usage
Immunohistochemistry (1:50~1:100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (without Mg2+ and Ca2+), 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human brain tissue with TGFBR2 (phospho S225/S250) polyclonal antibody (Cat# PAB29283) without blocking peptide (A) or preincubated with blocking peptide (B) under 1:50-1:100 dilution. -
Gene Info — TGFBR2
Entrez GeneID
7048Protein Accession#
P37173Gene Name
TGFBR2
Gene Alias
AAT3, FAA3, LDS1B, LDS2B, MFS2, RIIC, TAAD2, TGFR-2, TGFbeta-RII
Gene Description
transforming growth factor, beta receptor II (70/80kDa)
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq
Other Designations
TGF-beta receptor type IIB|TGF-beta type II receptor|transforming growth factor beta receptor type IIC|transforming growth factor, beta receptor II|transforming growth factor, beta receptor II (70-80kD)
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