CLK1 polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CLK1.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human CLK1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of CLK1 polyclonal antibody (Cat # PAB2924) in Y-79 cell line lysate. CLK1 (arrow) was detected using the purified polyclonal antibody. -
Gene Info — CLK1
Entrez GeneID
1195Protein Accession#
CLK1_HUMANGene Name
CLK1
Gene Alias
CLK, CLK/STY, STY
Gene Description
CDC-like kinase 1
Omim ID
601951Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
CDC28/CDC2-like kinase|dual specificity protein kinase CLK1|protein tyrosine kinase STY
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Interactome
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Publication Reference
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Regulation and substrate specificity of the SR protein kinase Clk/Sty.
Prasad J, Manley JL.
Molecular and Cellular Biology 2003 Jun; 23(12):4139.
Application:WB, Mouse, NIH/3T3 cells.
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Chromosomal mapping of three human LAMMER protein-kinase-encoding genes.
C B Talmadge, S Finkernagel, J Sumegi, L Sciorra, L Rabinow.
Human Genetics 1998 Oct; 103(4):523.
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Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases.
Hanes J, von der Kammer H, Klaudiny J, Scheit KH.
Journal of Molecular Biology 1994 Dec; 244(5):665.
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Regulation and substrate specificity of the SR protein kinase Clk/Sty.
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