MAP3K8 (phospho S400) polyclonal antibody

Catalog # PAB29208

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Quantity

Size:100 uL
Price: USD $ 346.00
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Contact Info
  • +1-909-264-1399
    +1-909-992-0619
    Toll Free : +1-877-853-6098
  • +1-909-992-3401
Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Application

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemical staining of human brain tissue by MAP3K8 (phospho S400) polyclonal antibody (Cat # PAB29208) without blocking peptide (A) or preincubated with blocking peptide (B) under 1:50-1:100 dilution.

  • Specification

    Product Description

    Rabbit polyclonal antibody raised against synthetic phosphopeptide of human MAP3K8.

    Immunogen

    Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S400 of human MAP3K8.

    Host

    Rabbit

    Theoretical MW (kDa)

    52

    Reactivity

    Human, Mouse, Rat

    Specificity

    This antibody detects endogenous levels of MAP3K8 only when phosphorylated at serine 400.

    Form

    Liquid

    Purification

    Affinity purification

    Recommend Usage

    Immunohistochemistry (1:50-1:100)
    The optimal working dilution should be determined by the end user.

    Storage Buffer

    In PBS, pH 7.4 (without Mg2+ and Ca2+), (50% glycerol, 0.02% sodium azide)

    Storage Instruction

    Store at -20°C.
    Avoid repeated freezing and thawing.

  • Applications

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

    Immunohistochemical staining of human brain tissue by MAP3K8 (phospho S400) polyclonal antibody (Cat # PAB29208) without blocking peptide (A) or preincubated with blocking peptide (B) under 1:50-1:100 dilution.
  • Gene Info — MAP3K8

    Entrez GeneID

    1326

    Protein Accession#

    P41279

    Gene Name

    MAP3K8

    Gene Alias

    COT, EST, ESTF, FLJ10486, TPL2, Tpl-2, c-COT

    Gene Description

    mitogen-activated protein kinase kinase kinase 8

    Omim ID

    191195 211980

    Gene Ontology

    Hyperlink

    Gene Summary

    This gene was identified by its oncogenic transforming activity in cells. The encoded protein is a member of the serine/threonine protein kinase family. This kinase can activate both the MAP kinase and JNK kinase pathways. This kinase was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This kinase was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. Studies of a similar gene in rat suggested the direct involvement of this kinase in the proteolysis of NF-kappaB1,p105 (NFKB1). This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. [provided by RefSeq

    Other Designations

    Cancer Osaka thyroid oncogene|Ewing sarcoma transformant|OTTHUMP00000019392|OTTHUMP00000019393|cot (cancer Osaka thyroid) oncogene|proto-oncogene serine/threoine protein kinase|tumor progression locus-2

  • Interactome
  • Pathway
  • Disease
Contact Info
  • +1-909-264-1399
    +1-909-992-0619
    Toll Free : +1-877-853-6098
  • +1-909-992-3401
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