MAPK7 polyclonal antibody
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More Files
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Western Blot (Cell lysate)
Western blot analysis of MAPK7 polyclonal antibody (Cat # PAB2891) in HL-60 cell lysate. MAPK7 (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with MAPK7 polyclonal antibody (Cat # PAB2891) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of MAPK7.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human MAPK7.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of MAPK7 polyclonal antibody (Cat # PAB2891) in HL-60 cell lysate. MAPK7 (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with MAPK7 polyclonal antibody (Cat # PAB2891) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma. -
Gene Info — MAPK7
Entrez GeneID
5598Protein Accession#
Q13164Gene Name
MAPK7
Gene Alias
BMK1, ERK4, ERK5, PRKM7
Gene Description
mitogen-activated protein kinase 7
Omim ID
602521Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq
Other Designations
BMK1 kinase|OTTHUMP00000065906|big MAP kinase 1|extracellular-signal-regulated kinase 5
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Interactome
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Pathway
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Disease
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Publication Reference
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Primary structure of BMK1: a new mammalian map kinase.
Lee JD, Ulevitch RJ, Han J.
Biochemical and Biophysical Research Communications 1995 Aug; 213(2):715.
Application：WB-Ti, Human, Human tissues.
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Components of a new human protein kinase signal transduction pathway.
Zhou G, Bao ZQ, Dixon JE.
The Journal of Biological Chemistry 1995 May; 270(21):12665.
Application：WB-Ce, WB-Re, WB-Tr, Human, Mammalian cells, Recombinant protein.
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Primary structure of BMK1: a new mammalian map kinase.
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