PANK1 polyclonal antibody
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More Files
- More Functions
Western Blot
Western blot analysis of PANK1 polyclonal antibody (Cat # PAB2717) in MCF-7 cell line (Lane 1) and mouse spleen tissue lysates (Lane 2)(35 ug/lane).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PANK1.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human PANK1.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis of PANK1 polyclonal antibody (Cat # PAB2717) in MCF-7 cell line (Lane 1) and mouse spleen tissue lysates (Lane 2)(35 ug/lane). -
Gene Info — PANK1
Entrez GeneID
53354Protein Accession#
NP_683878;Q8TE04Gene Name
PANK1
Gene Alias
MGC24596, PANK, PANK1a, PANK1b
Gene Description
pantothenate kinase 1
Omim ID
606160Gene Ontology
HyperlinkGene Summary
This gene encodes a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, have been identified. [provided by RefSeq
Other Designations
OTTHUMP00000020071|OTTHUMP00000020072|pantothenic acid kinase
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Pathway
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Disease
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Publication Reference
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PPARalpha controls the intracellular coenzyme A concentration via regulation of PANK1alpha gene expression.
Ramaswamy G, Karim MA, Murti KG, Jackowski S.
Journal of Lipid Research 2004 Jan; 45(1):17.
Application：IF, WB-Tr, Human, Monkey, COS-7, HepG2 cells.
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Cloning and characterization of a novel human pantothenate kinase gene.
Ni X, Ma Y, Cheng H, Jiang M, Ying K, Xie Y, Mao Y.
The International Journal of Biochemistry & Cell Biology 2002 Feb; 34(2):109.
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A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome.
Zhou B, Westaway SK, Levinson B, Johnson MA, Gitschier J, Hayflick SJ.
Nature Genetics 2001 Aug; 28(4):345.
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PPARalpha controls the intracellular coenzyme A concentration via regulation of PANK1alpha gene expression.
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