MITF polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of MITF.
Immunogen
A synthetic peptide corresponding to human MITF.
Host
Rabbit
Theoretical MW (kDa)
52
Reactivity
Human, Mouse
Specificity
MITF polyclonal antibody detects endogenous levels of MITF protein.
Form
Liquid
Purification
Antigen affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:200)
Immunofluorescence (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (0.05% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of COS-7 cell lysate with MITF polyclonal antibody (Cat # PAB27110).Immunohistochemistry
Immunofluorescence
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Gene Info — MITF
Entrez GeneID
4286Protein Accession#
O75030Gene Name
MITF
Gene Alias
MI, WS2A, bHLHe32
Gene Description
microphthalmia-associated transcription factor
Gene Ontology
HyperlinkGene Summary
This gene encodes a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq
Other Designations
OTTHUMP00000195123|OTTHUMP00000195140|homolog of mouse microphthalmia
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Interactome
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Pathway
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Disease
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Publication Reference
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An inhibitory mechanism of action of a novel syringic-acid derivative on α-melanocyte-stimulating hormone (α-MSH)-induced melanogenesis.
Jeong YJ, Lee JY, Park J, Park SN.
Life Sciences 2017 Dec; 191:52.
Application:WB-Ce, Mouse, B16F1 cells.
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An inhibitory mechanism of action of a novel syringic-acid derivative on α-melanocyte-stimulating hormone (α-MSH)-induced melanogenesis.
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