ZIC1/ZIC2/ZIC3 polyclonal antibody
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More Files
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Western Blot (Cell lysate)
Western blot analysis of Jurkat cell lysate with ZIC1/ZIC2/ZIC3 polyclonal antibody (Cat # PAB26961).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human brain tissue using ZIC1/ZIC2/ZIC3 polyclonal antibody (Cat # PAB26961).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ZIC1/ZIC2/ZIC3.
Immunogen
A synthetic peptide corresponding to human ZIC1/ZIC2/ZIC3.
Host
Rabbit
Theoretical MW (kDa)
51
Reactivity
Human, Mouse
Specificity
ZIC1/ZIC2/ZIC3 polyclonal antibody detects endogenous levels of ZIC1/ZIC2/ZIC3 protein.
Form
Liquid
Purification
Antigen affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:200)
Immunofluorescence (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (0.05% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of Jurkat cell lysate with ZIC1/ZIC2/ZIC3 polyclonal antibody (Cat # PAB26961).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human brain tissue using ZIC1/ZIC2/ZIC3 polyclonal antibody (Cat # PAB26961).Immunofluorescence
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Gene Info — ZIC1
Entrez GeneID
7545Protein Accession#
Q15915(Gene ID : 7545);O95409(Gene ID : 7546);O60481(Gene ID : 7547)Gene Name
ZIC1
Gene Alias
ZIC, ZNF201
Gene Description
Zic family member 1 (odd-paired homolog, Drosophila)
Omim ID
600470Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene. [provided by RefSeq
Other Designations
Zic family member 1 (odd-paired Drosophila homolog)|Zinc finger protein of the cerebellum 1|zinc finger protein of the cerebellum 1
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Gene Info — ZIC2
Entrez GeneID
7546Protein Accession#
Q15915(Gene ID : 7545);O95409(Gene ID : 7546);O60481(Gene ID : 7547)Gene Name
ZIC2
Gene Alias
HPE5
Gene Description
Zic family member 2 (odd-paired homolog, Drosophila)
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Mutations in this gene cause holoprosencephaly type 5. Holoprosencephaly is the most common structural anomaly of the human brain. A polyhistidine tract polymorphism in this gene may be associated with increased risk of neural tube defects. This gene is closely linked to a gene encoding zinc finger protein of the cerebellum 5, a related family member on chromosome 13. [provided by RefSeq
Other Designations
OTTHUMP00000018633|Zic family member 2 (odd-paired Drosophila homolog)|Zinc finger protein of the cerebellum 2|zinc finger protein of the cerebellum 2
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Gene Info — ZIC3
Entrez GeneID
7547Protein Accession#
Q15915(Gene ID : 7545);O95409(Gene ID : 7546);O60481(Gene ID : 7547)Gene Name
ZIC3
Gene Alias
HTX, HTX1, ZNF203
Gene Description
Zic family member 3 (odd-paired homolog, Drosophila)
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This nuclear protein probably functions as a transcription factor in early stages of left-right body axis formation. Mutations in this gene cause X-linked visceral heterotaxy, which includes congenital heart disease and left-right axis defects in organs. [provided by RefSeq
Other Designations
OTTHUMP00000024142|heterotaxy 1|zinc finger protein of the cerebellum 3
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Interactome
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Pathway
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Disease
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