GUCY1A3 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of GUCY1A3 polyclonal antibody (Cat # PAB2683) in mouse brain tissue lysate (35 ug/lane). GUCY1A3 (arrow) was detected using the purified polyclonal antibody.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with GUCY1A3 polyclonal antibody (Cat # PAB2683) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of GUCY1A3.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human GUCY1A3.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Ammonium sulfate precipitation
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of GUCY1A3 polyclonal antibody (Cat # PAB2683) in mouse brain tissue lysate (35 ug/lane). GUCY1A3 (arrow) was detected using the purified polyclonal antibody.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with GUCY1A3 polyclonal antibody (Cat # PAB2683) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma. -
Gene Info — GUCY1A3
Entrez GeneID
2982Protein Accession#
NP_000847;Q02108Gene Name
GUCY1A3
Gene Alias
GC-SA3, GUC1A3, GUCA3, GUCSA3, GUCY1A1
Gene Description
guanylate cyclase 1, soluble, alpha 3
Omim ID
139396Gene Ontology
HyperlinkGene Summary
Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha subunit, such as alpha-1 (GUCY1A3), and a beta subunit, typically beta-1 (GUCY1B3; MIM 139397), catalyzes conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide and nitrovasodilator drugs (Zabel et al., 1998 [PubMed 9742212]).[supplied by OMIM
Other Designations
GC-S-alpha-1|soluble guanylate cyclase large subunit
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Interactome
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Pathway
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Publication Reference
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Inhibition of angiogenesis in human glioma cell lines by antisense RNA from the soluble guanylate cyclase genes, GUCY1A3 and GUCY1B3.
Saino M, Maruyama T, Sekiya T, Kayama T, Murakami Y.
Oncology Reports 2004 Jul; 12(1):47.
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A novel Pax-6 binding site in rodent B1 repetitive elements: coevolution between developmental regulation and repeated elements?
Zhou Y, Zheng JB, Gu X, Li W, Saunders GF.
Gene 2000 Mar; 245(2):319.
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cGMP accumulation and gene expression of soluble guanylate cyclase in human vascular tissue.
Papapetropoulos A, Cziraki A, Rubin JW, Stone CD, Catravas JD.
Journal of Cellular Physiology 1996 May; 167(2):213.
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Inhibition of angiogenesis in human glioma cell lines by antisense RNA from the soluble guanylate cyclase genes, GUCY1A3 and GUCY1B3.
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