SCN1A polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human brain, cerebellum with SCN1A polyclonal antibody (Cat # PAB26052).
Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of SCN1A.
Immunogen
A synthetic peptide corresponding to 16 amino acids at N-terminus of human SCN1A.
Host
Rabbit
Reactivity
Chicken, Dog, Hamster, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat
Specificity
BLAST analysis of the peptide immunogen showed no homology with other human proteins, except SCN2A (100%), SCN3A (94%).
Form
Liquid
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human brain, cerebellum with SCN1A polyclonal antibody (Cat # PAB26052).
Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. -
Gene Info — SCN1A
Entrez GeneID
6323Protein Accession#
P35498Gene Name
SCN1A
Gene Alias
FEB3, GEFSP2, HBSCI, NAC1, Nav1.1, SCN1, SMEI
Gene Description
sodium channel, voltage-gated, type I, alpha subunit
Gene Ontology
HyperlinkGene Summary
The vertebrate sodium channel is a voltage-gated ion channel essential for the generation and propagation of action potentials, mainly in nerve and muscle. Voltage-sensitive sodium channels are heteromeric complexes consisting of a large central pore-forming glycosylated alpha subunit, and two smaller auxiliary beta subunits. This gene encodes the large alpha subunit, and mutations in this gene have been associated with several epilepsy, convulsion and migraine disorders
Other Designations
febrile convulsions 3|sodium channel protein, brain I alpha subunit|sodium channel, voltage-gated, type I, alpha|sodium channel, voltage-gated, type I, alpha polypeptide
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