MC1R polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of MC1R.
Immunogen
A synthetic peptide corresponding to MC1R.
Host
Rabbit
Theoretical MW (kDa)
35
Reactivity
Human
Specificity
MC1R polyclonal antibody detects endogenous levels of MC1R.
Form
Liquid
Purification
Antigen affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1:500-1:1000)
Immunofluorescence (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (0.05% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of COLO 205 cell extracts with MC1R polyclonal antibody (Cat # PAB25002).Immunofluorescence
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Gene Info — MC1R
Entrez GeneID
4157Gene Name
MC1R
Gene Alias
MGC14337, MSH-R, SHEP2
Gene Description
melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
Gene Ontology
HyperlinkGene Summary
This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. [provided by RefSeq
Other Designations
melanocortin 1 receptor|melanocyte stimulating hormone receptor|melanotropin receptor
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Interactome
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Pathway
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Disease
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