ABCB8 polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant ABCB8.
Immunogen
Recombinant protein corresponding to amino acids of human ABCB8.
Sequence
LFRVGIRGGPFPGRLLPPLRFQTFSAVRYSDGYRSSSLLRAVAHLRSQLWAHLPRAPLAPRWSPSAWCWVGGALLGPMVLSKHPHLCLVALCEAEEAPPASSTPHVVGSRFNWKLFWQFL
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:200-1:500)
Immunofluorescence (1-4 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human breast with ABCB8 polyclonal antibody (Cat # PAB24392) shows moderate cytoplasmic and nuclear positivity in glandular cells.Immunofluorescence
Immunofluorescent staining of human cell line U-251 MG with ABCB8 polyclonal antibody (Cat # PAB24392) at 1-4 ug/mL dilution shows positivity in nucleus and mitochondria. -
Gene Info — ABCB8
Entrez GeneID
11194Protein Accession#
Q9NUT2Gene Name
ABCB8
Gene Alias
EST328128, M-ABC1, MABC1
Gene Description
ATP-binding cassette, sub-family B (MDR/TAP), member 8
Omim ID
605464Gene Ontology
HyperlinkGene Summary
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. The function of this half-transporter has not yet been determined; however, it may involve the compartmentalization and transport of heme, as well as peptides, from the mitochondria to the nucleus and cytosol. This protein may also play a role in the transport of phospholipids into mitochondrial membranes. [provided by RefSeq
Other Designations
ATP-binding cassette, sub-family B, member 8|mitochondrial ABC protein
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Interactome
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Disease
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