SGK2 polyclonal antibody
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More Files
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Western Blot (Tissue lysate)
Western blot analysis of SGK2 polyclonal antibody (Cat # PAB2319) in placenta lysate. SKG2 (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the SGK2 polyclonal antibody (Cat # PAB2319) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of SGK2.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human SGK2.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of SGK2 polyclonal antibody (Cat # PAB2319) in placenta lysate. SKG2 (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the SGK2 polyclonal antibody (Cat # PAB2319) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma. -
Gene Info — SGK2
Entrez GeneID
10110Protein Accession#
Q9HBY8Gene Name
SGK2
Gene Alias
H-SGK2, dJ138B7.2
Gene Description
serum/glucocorticoid regulated kinase 2
Omim ID
607589Gene Ontology
HyperlinkGene Summary
This gene encodes a serine/threonine protein kinase. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase (SGK), this gene is not induced by serum or glucocorticoids. This gene is induced in response to signals that activate phosphatidylinositol 3-kinase, which is also true for SGK. Two alternate transcripts encoding two different isoforms have been described. [provided by RefSeq
Other Designations
OTTHUMP00000031702|OTTHUMP00000031703|OTTHUMP00000031705
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Interactome
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Publication Reference
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The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC.
Friedrich B, Feng Y, Cohen P, Risler T, Vandewalle A, Broer S, Wang J, Pearce D, Lang F.
Pflugers Archiv 2003 Mar; 445(6):693.
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Regulation of KCNE1-dependent K(+) current by the serum and glucocorticoid-inducible kinase (SGK) isoforms.
Embark HM, Bohmer C, Vallon V, Luft F, Lang F.
Pflügers Archiv: European Journal of Physiology 2003 Feb; 445(5):601.
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K+ channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK.
Gamper N, Fillon S, Feng Y, Friedrich B, Lang PA, Henke G, Huber SM, Kobayashi T, Cohen P, Lang F.
Pflügers Archiv 2002 Oct; 445(1):60.
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The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC.
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