EDARADD polyclonal antibody
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More Files
- More Functions
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human duodenum with EDARADD polyclonal antibody (Cat # PAB21049) shows distinct positivity in glandular cells at 1:50-1:200 dilution.
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant EDARADD.
Immunogen
Recombinant protein corresponding to amino acids of human EDARADD.
Sequence
PTISDLLNDQDLLDVIRIKLDPCHPTVKNWRNFASKWGMSYDELCFLEQRPQSPTLEFLLRNSQRTVGQLMELCRLYHRADVEKVLRRWVDEEWPKRERGDP
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human duodenum with EDARADD polyclonal antibody (Cat # PAB21049) shows distinct positivity in glandular cells at 1:50-1:200 dilution. -
Gene Info — EDARADD
Entrez GeneID
128178Protein Accession#
Q8WWZ3Gene Name
EDARADD
Gene Alias
ED3, EDA3
Gene Description
EDAR-associated death domain
Gene Ontology
HyperlinkGene Summary
This gene was identified by its association with ectodermal dysplasia, a genetic disorder characterized by defective development of hair, teeth, and eccrine sweat glands. The protein encoded by this gene is a death domain-containing protein, and is found to interact with EDAR, a death domain receptor known to be required for the development of hair, teeth and other ectodermal derivatives. This protein and EDAR are coexpressed in epithelial cells during the formation of hair follicles and teeth. Through its interaction with EDAR, this protein acts as an adaptor, and links the receptor to downstream signaling pathways. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq
Other Designations
EDAR-associated death domain protein|OTTHUMP00000037857|OTTHUMP00000037858|crinkled homolog|ectodysplasia A receptor associated death domain|ectodysplasin A receptor associated adapter protein
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