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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemical staining of human cerebellum with ABCG5 polyclonal antibody (Cat # PAB20881) shows strong cytoplasmic positivity in purkinje cells.

Entrez GeneID

64240

Protein Accession#

Q9H222

Gene Name

ABCG5

Gene Alias

STSL

Gene Description

ATP-binding cassette, sub-family G (WHITE), member 5

Omim ID

210250 605459

Gene Ontology

Hyperlink

Gene Summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions as a half-transporter to limit intestinal absorption and promote biliary excretion of sterols. It is expressed in a tissue-specific manner in the liver, colon, and intestine. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG8. Mutations in this gene may contribute to sterol accumulation and atheroschlerosis, and have been observed in patients with sitosterolemia. [provided by RefSeq

Other Designations

ATP-binding cassette sub-family G member 5|ATP-binding cassette, subfamily G, member 5|OTTHUMP00000158956|sterolin 1