CISD2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant CISD2.
Immunogen
Recombinant protein corresponding to amino acids of human CISD2.
Sequence
PKKKQQKDSLINLKIQKENPKVVNEINIEDLCLTKAAYCRCWRSKTFPACDGSHNKHNELTGDNVGPLILKKKEV
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:50-1:200)
Immunofluorescence (1-4 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human pancreas with CISD2 polyclonal antibody (Cat # PAB20855) shows strong cytoplasmic positivity in exocrine glandular cells at 1:50-1:200 dilution.Immunofluorescence
Immunofluorescent staining of human cell line U-251 MG with CISD2 polyclonal antibody (Cat # PAB20855) at 1-4 ug/mL dilution shows positivity in endoplasmic reticulum. -
Gene Info — CISD2
Entrez GeneID
493856Protein Accession#
Q8N5K1Gene Name
CISD2
Gene Alias
ERIS, Miner1, WFS2, ZCD2
Gene Description
CDGSH iron sulfur domain 2
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a zinc finger protein that localizes to the endoplasmic reticulum. The encoded protein binds an iron/sulfur cluster and may be involved in calcium homeostasis. Defects in this gene are a cause of Wolfram syndrome 2 (WFS2). [provided by RefSeq
Other Designations
endoplasmic reticulum intermembrane small protein|mitoNEET related 1|zinc finger, CDGSH-type domain 2
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Interactome
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Publication Reference
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CDGSH Iron Sulfur Domain 2 Deficiency Inhibits Cell Proliferation and Induces Cell Differentiation of Neuroblastoma.
Li J, Duan H, Xuan F, Zhao E, Huang M.
Pathology Oncology Research 2020 Jul; 26(3):1725.
Application:WB, Human, BE(2)-C, SHEP1, SH-SY5Y, SK-N-AS, SK-N-DZ cells.
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CDGSH Iron Sulfur Domain 2 Deficiency Inhibits Cell Proliferation and Induces Cell Differentiation of Neuroblastoma.
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