FGD1 polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human testis with FGD1 polyclonal antibody (Cat # PAB20017) shows moderate nuclear positivity in seminiferus duct.
Immunofluorescence
Immunofluorescent staining of human cell line U-2 OS with FGD1 polyclonal antibody (Cat # PAB20017) at 1-4 ug/mL dilution shows positivity in plasma membrane, cytoplasm.
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant FGD1.
Immunogen
Recombinant protein corresponding to amino acids of human FGD1.
Sequence
DSDPGASEPGLLARRGSGSALGGPLDPQFVGPSDTSLGAAPGHRVLPCGPSPQHHRALRFSYHLEGSQPRPGLHQGNRILVKSLSLDPGQSLEPHPEGPQRLRSDP
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:200-1:500)
Immunofluorescence (1-4 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human testis with FGD1 polyclonal antibody (Cat # PAB20017) shows moderate nuclear positivity in seminiferus duct.Immunofluorescence
Immunofluorescent staining of human cell line U-2 OS with FGD1 polyclonal antibody (Cat # PAB20017) at 1-4 ug/mL dilution shows positivity in plasma membrane, cytoplasm. -
Gene Info — FGD1
Entrez GeneID
2245Protein Accession#
P98174Gene Name
FGD1
Gene Alias
AAS, FGDY, ZFYVE3
Gene Description
FYVE, RhoGEF and PH domain containing 1
Gene Ontology
HyperlinkGene Summary
FGD1 contains Dbl (DH) and pleckstrin (PH) homology domains. It can bind specifically to the Rho family GTPase Cdc42Hs and stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. FGD1 has an essential role in embryonic development, and FGD1 gene mutations result in the human developmental disorder, Aarskog-Scott syndrome. [provided by RefSeq
Other Designations
OTTHUMP00000023372|faciogenital dysplasia protein
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Interactome
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Pathway
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