KLK4 polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of KLK4.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to internal region of human KLK4.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Ammonium sulfate precipitation
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of KLK4 polyclonal antibody (Cat # PAB1994) in mouse brain tissue lysate.KLK4 (arrow) was detected using the purified polyclonal antibody. -
Gene Info — KLK4
Entrez GeneID
9622Protein Accession#
NP_004908;Q9Y5K2Gene Name
KLK4
Gene Alias
ARM1, EMSP, EMSP1, KLK-L1, MGC116827, MGC116828, PROSTASE, PRSS17, PSTS
Gene Description
kallikrein-related peptidase 4
Gene Ontology
HyperlinkGene Summary
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In some tissues its expression is hormonally regulated. The expression pattern of a similar mouse protein in murine developing teeth supports a role for the protein in the degradation of enamel proteins. Alternate splice variants for this gene have been described, but their biological validity has not been determined. [provided by RefSeq
Other Designations
androgen-regulated message 1|enamel matrix serine protease 1|kallikrein 4 (prostase, enamel matrix, prostate)|kallikrein-like protein 1|protease, serine, 17
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Interactome
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Disease
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Publication Reference
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Mutation in kallikrein 4 causes autosomal recessive hypomaturation amelogenesis imperfecta.
Hart PS, Hart TC, Michalec MD, Ryu OH, Simmons D, Hong S, Wright JT.
Journal of Medical Genetics 2004 Jul; 41(7):545.
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Kallikrein 4 is a predominantly nuclear protein and is overexpressed in prostate cancer.
Xi Z, Klokk TI, Korkmaz K, Kurys P, Elbi C, Risberg B, Danielsen H, Loda M, Saatcioglu F.
Cancer Research 2004 Apr; 64(7):2365.
Application:IF, WB, Human, LNCaP cells.
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Identification of naturally processed CD4 T cell epitopes from the prostate-specific antigen kallikrein 4 using peptide-based in vitro stimulation.
Hural JA, Friedman RS, McNabb A, Steen SS, Henderson RA, Kalos M.
The Journal of Immunology 2002 Jul; 169(1):557.
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Mutation in kallikrein 4 causes autosomal recessive hypomaturation amelogenesis imperfecta.
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