NLRP11 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody rasied against synthetic peptide of NLRP11.
Immunogen
A synthetic peptide corresponding to 15 amino acids near C-terminus of human NLRP11.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Peptide affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1 ug/mL)
Immunocytochemistry (2.5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of NLRP11 in HeLa cell lysate with NLRP11 polyclonal antibody (Cat # PAB19308) at 1 ug/mL.Immunocytochemistry
Immunocytochemical staining of HeLa cells with NLRP11 polyclonal antibody (Cat # PAB19308) at 2.5 ug/mL.Enzyme-linked Immunoabsorbent Assay
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Gene Info — NLRP11
Entrez GeneID
204801Protein Accession#
NP_659444Gene Name
NLRP11
Gene Alias
CLR19.6, FLJ26273, NALP11, NOD17, PAN10, PYPAF6, PYPAF7
Gene Description
NLR family, pyrin domain containing 11
Omim ID
609664Gene Ontology
HyperlinkGene Summary
NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP11, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM
Other Designations
NACHT, LRR and PYD containing protein 11|NACHT, leucine rich repeat and PYD containing 11|PAAD- and NACHT-containing protein 10|PAAD- and NACHT-containing protein 10B|PYRIN-containing APAF1-like protein 6|nucleotide-binding oligomerization domain, leucine
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Disease
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