CAMK2B/CAMK2G/CAMK2D polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CAMK2B/CAMK2G/CAMK2D.
Immunogen
A synthetic peptide corresponding to residues surrounding T287 of human CAMK2B/CAMK2G/CAMK2D.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody is specific to CAMK2B/CAMK2G/CAMK2D.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
ELISA (1:5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of extracts from rat brain cells, using CAMK2B/CAMK2G/CAMK2D polyclonal antibody (Cat # PAB18512).
Peptide "+" means "peptide blocking".Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human brain tissue using CAMK2B/CAMK2G/CAMK2D polyclonal antibody (Cat # PAB18512).
Peptide "+" means "peptide blocking".Enzyme-linked Immunoabsorbent Assay
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Gene Info — CAMK2B
Entrez GeneID
816Gene Name
CAMK2B
Gene Alias
CAM2, CAMK2, CAMKB, MGC29528
Gene Description
calcium/calmodulin-dependent protein kinase II beta
Omim ID
607707Gene Ontology
HyperlinkGene Summary
The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Eight transcript variants encoding eight distinct isoforms have been identified for this gene. [provided by RefSeq
Other Designations
CaM kinase II beta subunit|CaM-kinase II beta chain|CaMK-II beta subunit|OTTHUMP00000159355|OTTHUMP00000159356|calcium/calmodulin-dependent protein kinase (CaM kinase) II beta|calcium/calmodulin-dependent protein kinase type II beta chain|proline rich cal
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Gene Info — CAMK2D
Entrez GeneID
817Gene Name
CAMK2D
Gene Alias
CAMKD, DKFZp686G23119, DKFZp686I2288, MGC44911
Gene Description
calcium/calmodulin-dependent protein kinase II delta
Omim ID
607708Gene Ontology
HyperlinkGene Summary
The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Distinct isoforms of this chain have different expression patterns
Other Designations
CaM kinase II delta subunit|CaM-kinase II delta chain|CaMK-II delta subunit|OTTHUMP00000163829|OTTHUMP00000163830|calcium/calmodulin-dependent protein kinase (CaM kinase) II delta|calcium/calmodulin-dependent protein kinase type II delta chain
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Gene Info — CAMK2G
Entrez GeneID
818Gene Name
CAMK2G
Gene Alias
CAMK, CAMK-II, CAMKG, FLJ16043, MGC26678
Gene Description
calcium/calmodulin-dependent protein kinase II gamma
Omim ID
602123Gene Ontology
HyperlinkGene Summary
The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a gamma chain. Six alternatively spliced variants that encode six different isoforms have been characterized to date. Additional alternative splice variants that encode different isoforms have been described, but their full-length nature has not been determined. [provided by RefSeq
Other Designations
CaM kinase II|OTTHUMP00000019843|OTTHUMP00000019844|calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma
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Interactome
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Pathway
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Disease
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Publication Reference
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The DNA sequence and comparative analysis of human chromosome 10.
Deloukas P, Earthrowl ME, Grafham DV, Rubenfield M, French L, Steward CA, Sims SK, Jones MC, Searle S, Scott C, Howe K, Hunt SE, Andrews TD, Gilbert JG, Swarbreck D, Ashurst JL, Taylor A, Battles J, Bird CP, Ainscough R, Almeida JP, Ashwell RI, Ambrose KD, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Bates K, Beasley H, Bray-Allen S, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Cahill P, Camire D, Carter NP, Chapman JC, Clark SY, Clarke G, Clee CM, Clegg S, Corby N, Coulson A, Dhami P,
Nature 2004 May; 429(6990):375.
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Identification of alternative splicing variants of the beta subunit of human Ca(2+)/calmodulin-dependent protein kinase II with different activities.
Wang P, Wu YL, Zhou TH, Sun Y, Pei G.
FEBS Letters 2000 Jun; 475(2):107.
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The DNA sequence and comparative analysis of human chromosome 10.
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