KIR2DL5B polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of KIR2DL5B.
Immunogen
A synthetic peptide corresponding to internal of human KIR2DL5B.
Host
Rabbit
Reactivity
Human
Specificity
This antibody detects endogenous levels of total KIR2DL5B protein.
Form
Liquid
Recommend Usage
Immunofluorescence (1:500-1:1000)
ELISA (1:40000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (150mM NaCl, 0.02% sodium azide, 50% glycerol)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunofluorescence
Immunofluorescence analysis of A-549 cells, using KIR2DL5B polyclonal antibody (Cat # PAB17754).
Peptide "+" means "with peptide blocking".Enzyme-linked Immunoabsorbent Assay
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Gene Info — KIR2DL5B
Entrez GeneID
553128Protein Accession#
Q8NHK3Gene Name
KIR2DL5B
Gene Alias
KIR2DL5, KIR2DL5.2, KIR2DLX
Gene Description
killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5B
Gene Ontology
HyperlinkGene Summary
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq
Other Designations
killer cell Ig-like receptor
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Disease
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