CYP2B6 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CYP2B6.
Immunogen
A synthetic peptide corresponding to internal of human CYP2B6.
Host
Rabbit
Reactivity
Human
Specificity
This antibody detects endogenous levels of total CYP2B6 protein.
Form
Liquid
Recommend Usage
Western Blot (1:500-1:1000)
ELISA (1:10000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (150mM NaCl, 0.02% sodium azide, 50% glycerol)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from HT-29 cells, using CYP2B6 polyclonal antibody (Cat # PAB17526).
Peptide "+" means "with peptide blocking".Enzyme-linked Immunoabsorbent Assay
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Gene Info — CYP2B6
Entrez GeneID
1555Protein Accession#
P20813Gene Name
CYP2B6
Gene Alias
CPB6, CYP2B, CYPIIB6, IIB1, P450
Gene Description
cytochrome P450, family 2, subfamily B, polypeptide 6
Omim ID
123930Gene Ontology
HyperlinkGene Summary
This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq
Other Designations
cytochrome P450, subfamily IIB (phenobarbital-inducible), polypeptide 6
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