Products

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemistry analysis of paraffin-embedded human brain tissue using COL4A4 polyclonal antibody (Cat # PAB17512).
Peptide "+" means "with peptide blocking".

Immunofluorescence

Immunofluorescence analysis of COS-7 cells, using COL4A4 polyclonal antibody (Cat # PAB17512).
Peptide "+" means "with peptide blocking".

Enzyme-linked Immunoabsorbent Assay

Entrez GeneID

1286

Protein Accession#

P53420

Gene Name

COL4A4

Gene Alias

CA44

Gene Description

collagen, type IV, alpha 4

Omim ID

120131 203780

Gene Ontology

Hyperlink

Gene Summary

This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. This particular collagen IV subunit, however, is only found in a subset of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. Mutations in this gene are associated with type II autosomal recessive Alport syndrome (hereditary glomerulonephropathy) and with familial benign hematuria (thin basement membrane disease). Two transcripts, differing only in their transcription start sites, have been identified for this gene and, as is common for collagen genes, multiple polyadenylation sites are found in the 3' UTR. [provided by RefSeq

Other Designations

Collagen IV, alpha-4 polypeptide|OTTHUMP00000195046|alpha 4 type IV collagen|collagen of basement membrane, alpha-4 chain