PREX1 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
PREX1 polyclonal antibody (Cat # PAB17234) (1 ug/mL) staining of human temporal cortex lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of PREX1.
Immunogen
A synthetic peptide corresponding to amino acids at internal region of human PREX1.
Sequence
C-ERSNLPTDASTTA
Host
Goat
Theoretical MW (kDa)
186
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:16000)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
PREX1 polyclonal antibody (Cat # PAB17234) (1 ug/mL) staining of human temporal cortex lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — PREX1
Entrez GeneID
57580Protein Accession#
NP_065871.2Gene Name
PREX1
Gene Alias
KIAA1415, P-REX1
Gene Description
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
Omim ID
606905Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins. [provided by RefSeq
Other Designations
OTTHUMP00000031228|phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Upregulation of PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer metastasis.
Qin J, Xie Y, Wang B, Hoshino M, Wolff DW, Zhao J, Scofield MA, Dowd FJ, Lin MF, Tu Y.
Oncogene 2009 Mar; 28(16):1853.
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Upregulation of PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer metastasis.
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