RNF168 polyclonal antibody
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More Files
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Western Blot (Tissue lysate)
Western blot analysis of RNF168 in human brain tissue lysate with RNF168 polyclonal antibody (Cat # PAB16741) at 1 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of RNF168.
Immunogen
A synthetic peptide corresponding to C-terminus 18 amino acids of human RNF168.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of RNF168 in human brain tissue lysate with RNF168 polyclonal antibody (Cat # PAB16741) at 1 ug/mL .Enzyme-linked Immunoabsorbent Assay
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Gene Info — RNF168
Entrez GeneID
165918Protein Accession#
NP_689830Gene Name
RNF168
Gene Alias
FLJ35794
Gene Description
ring finger protein 168
Gene Ontology
HyperlinkGene Summary
The complex repair response elicited by DNA double-strand breaks (DSBs) includes recruitment of several DNA repair proteins and ubiquitination of H2A-type histones (see MIM 142720). RNF168 is an E3 ubiquitin ligase critical for DSB repair (Stewart et al., 2009 [PubMed 19203578]).[supplied by OMIM
Other Designations
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Interactome
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Publication Reference
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RNF168, a new RING finger, MIU-containing protein that modifies chromatin by ubiquitination of histones H2A and H2AX.
Pinato S, Scandiuzzi C, Arnaudo N, Citterio E, Gaudino G, Penengo L.
BMC Molecular Biology 2009 Jun; 10:55.
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RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins.
Doil C, Mailand N, Bekker-Jensen S, Menard P, Larsen DH, Pepperkok R, Ellenberg J, Panier S, Durocher D, Bartek J, Lukas J, Lukas C.
Cell 2009 Feb; 136(3):435.
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RNF168, a new RING finger, MIU-containing protein that modifies chromatin by ubiquitination of histones H2A and H2AX.
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