NDP polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of NDP.
Immunogen
A synthetic peptide corresponding to N-terminus 18 amino acids from of human NDP.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of NDP in Jurkat cell lysate with NDP polyclonal antibody (Cat # PAB16728) at (A) 1 and (B) 2 ug/mL .Immunocytochemistry
Immunocytochemistry of NDP in Jurkat cells with NDP polyclonal antibody (Cat # PAB16728) at 5 ug/mL .Enzyme-linked Immunoabsorbent Assay
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Gene Info — NDP
Entrez GeneID
4693Protein Accession#
NP_000257Gene Name
NDP
Gene Alias
EVR2, FEVR, ND
Gene Description
Norrie disease (pseudoglioma)
Gene Ontology
HyperlinkGene Summary
This gene encodes a secreted protein with a cystein-knot motif that activates the Wnt/beta-catenin pathway. The protein forms disulfide-linked oligomers in the extracellular matrix. Mutations in this gene result in Norrie disease and X-linked exudative vitreoretinopathy. [provided by RefSeq
Other Designations
OTTHUMP00000023168|norrin
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Interactome
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Disease
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Publication Reference
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Characterization and Molecular Profiling of PSEN1 Familial Alzheimer's Disease iPSC-Derived Neural Progenitors.
Sproul AA, Jacob S, Pre D, Kim SH, Nestor MW, Navarro-Sobrino M, Santa-Maria I, Zimmer M, Aubry S, Steele JW, Kahler DJ, Dranovsky A, Arancio O, Crary JF, Gandy S, Noggle SA.
PLoS One 2014 Jan; 9(1):e84547.
Application:IS, Human, Brain.
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Ectopic norrin induces growth of ocular capillaries and restores normal retinal angiogenesis in Norrie disease mutant mice.
Ohlmann A, Scholz M, Goldwich A, Chauhan BK, Hudl K, Ohlmann AV, Zrenner E, Berger W, Cvekl A, Seeliger MW, Tamm ER.
The Journal of Neuroscience 2005 Feb; 25(7):1701.
Application:IHC-P, Mouse, Eye.
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Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair.
Xu Q, Wang Y, Dabdoub A, Smallwood PM, Williams J, Woods C, Kelley MW, Jiang L, Tasman W, Zhang K, Nathans J.
Cell 2004 Mar; 116(6):883.
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Molecular modelling of the Norrie disease protein predicts a cystine knot growth factor tertiary structure.
Meitinger T, Meindl A, Bork P, Rost B, Sander C, Haasemann M, Murken J.
Nature Genetics 1993 Dec; 5(4):376.
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Characterization and Molecular Profiling of PSEN1 Familial Alzheimer's Disease iPSC-Derived Neural Progenitors.
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