ITGA4 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of ITGA4 in rat spleen tissue lysate with ITGA4 polyclonal antibody (Cat # PAB16606) at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.
Immunofluorescence
Immunofluorescence of ITGA4 in Jurkat cells with ITGA4 polyclonal antibody (Cat # PAB16606) at 2 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ITGA4.
Immunogen
A synthetic peptide corresponding to internal region 15 amino acids of human ITGA4.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (0.5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of ITGA4 in rat spleen tissue lysate with ITGA4 polyclonal antibody (Cat # PAB16606) at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.Immunofluorescence
Immunofluorescence of ITGA4 in Jurkat cells with ITGA4 polyclonal antibody (Cat # PAB16606) at 2 ug/mL .Enzyme-linked Immunoabsorbent Assay
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Gene Info — ITGA4
Entrez GeneID
3676Protein Accession#
P13612Gene Name
ITGA4
Gene Alias
CD49D, IA4, MGC90518
Gene Description
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
Omim ID
192975Gene Ontology
HyperlinkGene Summary
The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain. [provided by RefSeq
Other Designations
269C wild type|antigen CD49D, alpha-4 subunit of VLA-4 receptor|integrin alpha 4|integrin alpha-4 subunit|very late activation protein 4 receptor, alpha 4 subunit
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Interactome
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Pathway
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Disease
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Publication Reference
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Transmembrane and cytoplasmic domains in integrin activation and protein-protein interactions (review).
Wegener KL, Campbell ID.
Molecular Membrane Biology 2008 Aug; 25(5):376.
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Identification of putative ligand-binding sites of the integrin alpha 4 beta 1 (VLA-4, CD49d/CD29).
Kamata T, Puzon W, Takada Y.
The Biochemical Journal 1995 Feb; 305 ( Pt 3)(Pt 3):945.
Application：Flow Cyt, Func, IP, Hamster, CHO-K1 cells.
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Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1.
Berlin C, Berg EL, Briskin MJ, Andrew DP, Kilshaw PJ, Holzmann B, Weissman IL, Hamann A, Butcher EC.
Cell 1993 Jul; 74(1):185.
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Transmembrane and cytoplasmic domains in integrin activation and protein-protein interactions (review).
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