ACVR1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ACVR1.
Immunogen
A synthetic peptide corresponding to N-terminus 14 amino acids of human ACVR1.
Host
Rabbit
Reactivity
Human, Mouse
Specificity
Specific of ACVR1 antibody.
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of ACVR1 in A-549 cell lysate with ACVR1 polyclonal antibody (Cat # PAB16547) at 1 ug/mL in (Lane 1) the absence and (Lane 2) the presence of blocking peptide.Enzyme-linked Immunoabsorbent Assay
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Gene Info — ACVR1
Entrez GeneID
90Protein Accession#
NP_001096Gene Name
ACVR1
Gene Alias
ACTRI, ACVR1A, ACVRLK2, ALK2, FOP, SKR1, TSRI
Gene Description
activin A receptor, type I
Gene Ontology
HyperlinkGene Summary
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq
Other Designations
TGF-B superfamily receptor type I|activin A receptor, type II-like kinase 2|activin A type I receptor|hydroxyalkyl-protein kinase|serine/threonine-protein kinase receptor R1
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Interactome
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Pathway
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Disease
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Publication Reference
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Activin receptor-like kinase-2 inhibits activin signaling by blocking the binding of activin to its type II receptor.
Renlund N, O'Neill FH, Zhang L, Sidis Y, Teixeira J.
The Journal of Endocrinology 2007 Oct; 195(1):95.
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Mullerian inhibiting substance signaling uses a bone morphogenetic protein (BMP)-like pathway mediated by ALK2 and induces SMAD6 expression.
Clarke TR, Hoshiya Y, Yi SE, Liu X, Lyons KM, Donahoe PK.
Molecular Endocrinology 2001 Jun; 15(6):946.
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Activin receptor-like kinase-2 inhibits activin signaling by blocking the binding of activin to its type II receptor.
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