ALDH3A1 polyclonal antibody
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More Files
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Specifications
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ALDH3A1.
Immunogen
A synthetic peptide corresponding to C-terminus 13 amino acids of human ALDH3A1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of ALDH3A1 in human stomach lysate with ALDH3A1 polyclonal antibody (Cat # PAB16545) at (Lane 1) 1 and (Lane 2) 2 ug/mL .Enzyme-linked Immunoabsorbent Assay
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Gene Info — ALDH3A1
Entrez GeneID
218Protein Accession#
NP_000682Gene Name
ALDH3A1
Gene Alias
ALDH3, ALDHIII, MGC10406
Gene Description
aldehyde dehydrogenase 3 family, memberA1
Omim ID
100660Gene Ontology
HyperlinkGene Summary
Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq
Other Designations
aldehyde dehydrogenase 3A1|aldehyde dehydrogenase isozyme 3|aldehyde dehydrogenase type III|aldehyde dehydrogenase, dimeric NADP-preferring|stomach aldehyde dehydrogenase
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Interactomes
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Pathways
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Diseases
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Publication Reference
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Mechanisms involved in the protection of UV-induced protein inactivation by the corneal crystallin ALDH3A1.
Estey T, Cantore M, Weston PA, Carpenter JF, Petrash JM, Vasiliou V.
The Journal of Biological Chemistry 2007 Feb; 282(7):4382.
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Corneal and stomach expression of aldehyde dehydrogenases: from fish to mammals.
Pappa A, Sophos NA, Vasiliou V.
Chemico-Biological Interactions 2001 Jan; 130-132(1-3):181.
Application:WB-Ti, Pig, Mouse, Rat, Chicken, Turkey, Rabbit, Frog, Zebrafish, T, Eye, Stomach.
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Polymorphisms of human aldehyde dehydrogenases. Consequences for drug metabolism and disease.
Vasiliou V, Pappa A.
Pharmacology 2000 Sep; 61(3):192.
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Mechanisms involved in the protection of UV-induced protein inactivation by the corneal crystallin ALDH3A1.
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