Gabbr2 polyclonal antibody
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More Files
- More Functions
Western Blot
Western blotting analysis of Gabbr2 in rat liver (lane 1), GB2-transfected HEK292 cells (Lane 2) and rat brain (Lane 3) with Gabbr2 polyclonal antibody (Cat # PAB14688).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of Gabbr2.
Immunogen
A synthetic peptide (conjugated with THG) corresponding to C-terminus last 23 amino acids of mouse Gabbr2.
Host
Rabbit
Theoretical MW (kDa)
120
Reactivity
Mouse, Rat
Specificity
This antibody recognizes C-terminus of gamma-aminobutyric acid (GABA) B receptor 2 (recognized epitope: the last 23 aa). GB2 apparent MW ~120 KDa.
Form
Liquid
Recommend Usage
Western Blot (0.6 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blotting analysis of Gabbr2 in rat liver (lane 1), GB2-transfected HEK292 cells (Lane 2) and rat brain (Lane 3) with Gabbr2 polyclonal antibody (Cat # PAB14688).Immunocytochemistry
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Gene Info — Gabbr2
Entrez GeneID
242425Gene Name
Gabbr2
Gene Alias
GABABR2, Gb2, Gm425, Gpr51
Gene Description
gamma-aminobutyric acid (GABA) B receptor 2
Gene Ontology
HyperlinkGene Summary
subunit 2|ortholog of human G protein-coupled receptor 51 GPR51
Other Designations
G protein-coupled receptor 51|GABA-B receptor 2|OTTMUSP00000007177|gamma-aminobutyric acid type B receptor, subunit 2|ortholog of human G protein-coupled receptor 51 GPR51
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Publication Reference
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No ligand binding in the GB2 subunit of the GABA(B) receptor is required for activation and allosteric interaction between the subunits.
Kniazeff J, Galvez T, Labesse G, Pin JP.
Journal of Neuroscience 2002 Sep; 22(17):7352.
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Function of GB1 and GB2 subunits in G protein coupling of GABA(B) receptors.
Margeta-Mitrovic M, Jan YN, Jan LY.
PNAS 2001 Nov; 98(25):14649.
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Ligand-induced signal transduction within heterodimeric GABA(B) receptor.
Margeta-Mitrovic M, Jan YN, Jan LY.
PNAS 2001 Dec; 98(25):14643.
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No ligand binding in the GB2 subunit of the GABA(B) receptor is required for activation and allosteric interaction between the subunits.
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