GHRL polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Paraffin-embedded sheep abomasum was incubated in GHRL polyclonal antibody (Cat # PAB14308) at the dilution of 1 : 1000 overnight followed by incubation with biotinylated secondary antibodies. Cell bodies and nerve terminals in the sheep abomasum are intensely stained. This figure shows staining of cells when no pre-absorption is performed.
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Specification
Product Description
Guinea pig polyclonal antibody raised against synthetic peptide of GHRL.
Immunogen
A synthetic peptide (conjugated with carrier protein) corresponding to amino acids 24-51 of human GHRL.
Sequence
GSSFLSPEHQRVQQRKESKKPPAKLQPR
Host
Guinea pig
Reactivity
Human, Sheep
Form
Lyophilized
Recommend Usage
Immunohistochemistry (1:3000)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from PBS
Storage Instruction
Store at 4°C on dry atmosphere.
After reconstitution with deionized water, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing. -
Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Paraffin-embedded sheep abomasum was incubated in GHRL polyclonal antibody (Cat # PAB14308) at the dilution of 1 : 1000 overnight followed by incubation with biotinylated secondary antibodies. Cell bodies and nerve terminals in the sheep abomasum are intensely stained. This figure shows staining of cells when no pre-absorption is performed. -
Gene Info — GHRL
Entrez GeneID
51738Protein Accession#
Q9UBU3Gene Name
GHRL
Gene Alias
MTLRP, obestatin
Gene Description
ghrelin/obestatin prepropeptide
Gene Ontology
HyperlinkGene Summary
This gene encodes ghrelin-obestatin preproprotein, which generates ghrelin and obestatin. Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor and is involved in regulating growth hormone release. Obestatin was initially reported to be an endogenous ligand for the orphan G protein-coupled receptor GPR39 and was involved in satiety and decreased food intake; however, these findings are controversial. Recent reports show that obestatin is involved in inhibiting thirst and anxiety, improving memory, regulating sleep, affecting cell proliferation, and increasing the secretion of pancreatic juice enzymes. Alternative promoters and alternative splicing result in multiple transcript variants, some of which encode different protein isoforms and some of which do not encode a protein but may regulate the ghrelin-obestatin preproprotein expression. In addition, antisense transcripts for this gene have been identified and may also function in regulation of the ghrelin-obestatin preproprotein expression. [provided by RefSeq
Other Designations
ghrelin, growth hormone secretagogue receptor ligand|ghrelin/obestatin|ghrelin/obestatin preprohormone|motilin-related peptide
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Interactome
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Pathway
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Disease
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Publication Reference
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Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor.
Kojima M, Hosoda H, Matsuo H, Kangawa K.
Trends in Endocrinology and Metabolism 2001 Apr; 12(3):118.
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Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor.
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