DLX5 polyclonal antibody
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More Files
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Western Blot (Tissue lysate)
DLX5 polyclonal antibody (Cat # PAB13670) (1 ug/mL) staining of human bone marrow lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of DLX5.
Immunogen
A synthetic peptide corresponding to amino acids at internal region of human DLX5.
Sequence
C-AYNRVPSATNQPEK
Host
Goat
Theoretical MW (kDa)
31.5
Reactivity
Human
Specificity
Approximately 30 KDa band observed in human bone marrow lysates (calculated MW of 31.5 KDa according to NP_005212.1). The observed molecular weight corresponds to earlier findings in literature with different antibodies (Lee et al, J Biol Chem. 2003 Sep 5;278(36):34387-94; PMID: 12815054).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:32000)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
DLX5 polyclonal antibody (Cat # PAB13670) (1 ug/mL) staining of human bone marrow lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — DLX5
Entrez GeneID
1749Protein Accession#
NP_005212.1Gene Name
DLX5
Gene Alias
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Gene Description
distal-less homeobox 5
Omim ID
600028Gene Ontology
HyperlinkGene Summary
This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. The encoded protein may play a role in bone development and fracture healing. Mutation in this gene, which is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 7, may be associated with split-hand/split-foot malformation. [provided by RefSeq
Other Designations
distal-less homeo box 5
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Interactome
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Disease
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Publication Reference
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DLX5 and HOXC8 enhance the chondrogenic differentiation potential of stem cells from apical papilla via LINC01013.
Haoqing Yang, Yangyang Cao, Jianpeng Zhang, Yuncun Liang, Xiaomin Su, Chen Zhang, Huina Liu, Xiao Han, Lihua Ge, Zhipeng Fan.
Stem Cell Research & Therapy 2020 Jul; 11(1):271.
Application：IP, WB-Tr, Human, Stem cells from apical papilla.
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Distal-less homeobox 5 promotes the osteo-/dentinogenic differentiation potential of stem cells from apical papilla by activating histone demethylase KDM4B through a positive feedback mechanism.
Yang H, Fan J, Cao Y, Gao R, Fan Z.
Experimental Cell Research 2019 Jan; 374(1):221.
Application：WB-Ce, WB-Tr, Human, HEK 293T cells, Stem cells from apical papilla.
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A novel recurrent chromosomal inversion implicates the homeobox gene Dlx5 in T-cell lymphomas from Lck-Akt2 transgenic mice.
Tan Y, Timakhov RA, Rao M, Altomare DA, Xu J, Liu Z, Gao Q, Jhanwar SC, Di Cristofano A, Wiest DL, Knepper JE, Testa JR.
Cancer Research 2008 Mar; 68(5):1296.
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DLX5 and HOXC8 enhance the chondrogenic differentiation potential of stem cells from apical papilla via LINC01013.
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