POFUT1 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of POFUT1 in human heart tissue lysate with POFUT1 polyclonal antibody (Cat # PAB13063) at (A) 0.5 and (B) 1 ug/mL .
Immunohistochemistry
Immunohistochemical staining of human heart tissue with 2.5 ug/mL POFUT1 polyclonal antibody (Cat # PAB13063).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of POFUT1.
Immunogen
A synthetic peptide corresponding to N-terminus 16 amino acids of human POFUT1.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of POFUT1 in human heart tissue lysate with POFUT1 polyclonal antibody (Cat # PAB13063) at (A) 0.5 and (B) 1 ug/mL .Immunohistochemistry
Immunohistochemical staining of human heart tissue with 2.5 ug/mL POFUT1 polyclonal antibody (Cat # PAB13063). -
Gene Info — POFUT1
Entrez GeneID
23509Protein Accession#
NP_056167Gene Name
POFUT1
Gene Alias
FUT12, KIAA0180, MGC2482, O-FUT, O-Fuc-T, O-FucT-1
Gene Description
protein O-fucosyltransferase 1
Omim ID
607491Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the glycosyltransferase O-Fuc family. This enzyme adds O-fucose through an O-glycosidic linkage to conserved serine or threonine residues in the epidermal growth factor-like repeats of a number of cell surface and secreted proteins. O-fucose glycans are involved in ligand-induced receptor signaling. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq
Other Designations
GDP-fucose protein O-fucosyltransferase 1|OTTHUMP00000030583|OTTHUMP00000030584|o-fucosyltransferase protein
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Interactome
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Disease
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Publication Reference
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Roles of Pofut1 and O-fucose in mammalian Notch signaling.
Stahl M, Uemura K, Ge C, Shi S, Tashima Y, Stanley P.
The Journal of Biological Chemistry 2008 May; 283(20):13638.
Application：WB, Mouse, Lec13 cells.
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Molecular evolution of protein O-fucosyltransferase genes and splice variants.
Loriol C, Dupuy F, Rampal R, Dlugosz MA, Haltiwanger RS, Maftah A, Germot A.
Glycobiology 2006 Aug; 16(8):736.
Application：WB-Tr, Monkey, COS-1 cells.
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Modification of epidermal growth factor-like repeats with O-fucose. Molecular cloning and expression of a novel GDP-fucose protein O-fucosyltransferase.
Wang Y, Shao L, Shi S, Harris RJ, Spellman MW, Stanley P, Haltiwanger RS.
The Journal of Biological Chemistry 2001 Oct; 276(43):40338.
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Roles of Pofut1 and O-fucose in mammalian Notch signaling.
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