UNC93B1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of UNC93B1.
Immunogen
A synthetic peptide corresponding to N-terminus 19 amino acids of human UNC93B1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of UNC93B1 in human heart tissue lysate with UNC93B1 polyclonal antibody (Cat # PAB13029) at (A) 0.5 and (B) 1 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of UNC93B1 in human heart with UNC93B1 polyclonal antibody (Cat # PAB13029) at 2.5 ug/mL . -
Gene Info — UNC93B1
Entrez GeneID
81622Protein Accession#
AAH33623Gene Name
UNC93B1
Gene Alias
MGC126617, UNC93, UNC93B
Gene Description
unc-93 homolog B1 (C. elegans)
Gene Ontology
HyperlinkGene Summary
This gene encodes a protein with similarity to the C. elegans unc93 protein. The Unc93 protein is involved in the regulation or coordination of muscle contraction in the worm. [provided by RefSeq
Other Designations
unc-93 homolog B1|unc-93 related protein|unc93 homolog B|unc93 homolog B1
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Interactome
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Publication Reference
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Expression of murine Unc93b1 is up-regulated by interferon and estrogen signaling: implications for sex bias in the development of autoimmunity.
Panchanathan R, Liu H, Choubey D.
International Immunology 2013 Sep; 25(9):521.
Application:WB-Ce, WB-Tr, Mouse, CD3+, B220+, CD11b+ , CD11c+, Splenic, J774.A1 cells.
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The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling.
Brinkmann MM, Spooner E, Hoebe K, Beutler B, Ploegh HL, Kim YM.
The Journal of Cell Biology 2007 Apr; 177(2):265.
Application:IP, Mouse, Mouse bone marrow-derived dendritic cells.
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The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9.
Tabeta K, Hoebe K, Janssen EM, Du X, Georgel P, Crozat K, Mudd S, Mann N, Sovath S, Goode J, Shamel L, Herskovits AA, Portnoy DA, Cooke M, Tarantino LM, Wiltshire T, Steinberg BE, Grinstein S, Beutler B.
Nature Immunology 2006 Feb; 7(2):156.
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The human homologue of unc-93 maps to chromosome 6q27 - characterisation and analysis in sporadic epithelial ovarian cancer.
Liu Y, Dodds P, Emilion G, Mungall AJ, Dunham I, Beck S, Wells RS, Charnock FM, Ganesan TS.
BMC Genetics 2002 Oct; 3:20.
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Expression of murine Unc93b1 is up-regulated by interferon and estrogen signaling: implications for sex bias in the development of autoimmunity.
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