MAP3K7IP1 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of MAP3K7IP1 in NIH/3T3 cell lysate with MAP3K7IP1 polyclonal antibody (Cat # PAB12935) at (A) 0.5, (B) 1, and (C) 2 ug/mL .
Immunocytochemistry
Immunocytochemistry of MAP3K7IP1 in K-562 cells with MAP3K7IP1 polyclonal antibody (Cat # PAB12935) at 1 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of MAP3K7IP1.
Immunogen
A synthetic peptide corresponding to internal region 13 amino acids of human MAP3K7IP1.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of MAP3K7IP1 in NIH/3T3 cell lysate with MAP3K7IP1 polyclonal antibody (Cat # PAB12935) at (A) 0.5, (B) 1, and (C) 2 ug/mL .Immunocytochemistry
Immunocytochemistry of MAP3K7IP1 in K-562 cells with MAP3K7IP1 polyclonal antibody (Cat # PAB12935) at 1 ug/mL . -
Gene Info — MAP3K7IP1
Entrez GeneID
10454Protein Accession#
NP_006107Gene Name
MAP3K7IP1
Gene Alias
3'-Tab1, MGC57664, TAB1
Gene Description
mitogen-activated protein kinase kinase kinase 7 interacting protein 1
Omim ID
602615Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq
Other Designations
TAK1-binding protein 1|transforming growth factor beta-activated kinase-binding protein 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Toll-like receptor signalling.
Akira S, Takeda K.
Nature Reviews. Immunology 2004 Jul; 4(7):499.
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Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol.
Jiang Z, Ninomiya-Tsuji J, Qian Y, Matsumoto K, Li X.
Molecular and Cellular Biology 2002 Oct; 22(20):7158.
Application：WB-Tr, Human, HEK 293 cells.
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TAK1 mediates an activation signal from toll-like receptor(s) to nuclear factor-kappaB in lipopolysaccharide-stimulated macrophages.
Irie T, Muta T, Takeshige K.
FEBS Letters 2000 Feb; 467(2-3):160.
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Toll-like receptor signalling.
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