DUOX2 polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of DUOX2.
Immunogen
A synthetic peptide corresponding to amino acids 400-500 of human DUOX2.
Host
Rabbit
Reactivity
Dog, Human, Mouse, Pig, Rat
Form
Liquid
Recommend Usage
Western Blot (2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (30% glycerol, 0.09% sodium azide)
Storage Instruction
Store at 4°C for short term. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of DUOX2 in A-549 in cell lysate using DUOX2 polyclonal antibody (Cat # PAB12443). -
Gene Info — DUOX2
Entrez GeneID
50506Protein Accession#
Q9NRD8Gene Name
DUOX2
Gene Alias
LNOX2, NOXEF2, P138-TOX, THOX2
Gene Description
dual oxidase 2
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX1. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. [provided by RefSeq
Other Designations
NADH/NADPH thyroid oxidase p138-tox|NADPH oxidase/peroxidase DUOX2|NADPH thyroid oxidase 2|OTTHUMP00000162044|dual oxidase-like domains 2|flavoprotein NADPH oxidase|nicotinamide adenine dinucleotide phosphate oxidase
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Disease
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Publication Reference
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Differential regulation of dual NADPH oxidases/peroxidases, Duox1 and Duox2, by Th1 and Th2 cytokines in respiratory tract epithelium.
Harper RW, Xu C, Eiserich JP, Chen Y, Kao CY, Thai P, Setiadi H, Wu R.
FEBS Letters 2005 Aug; 579(21):4911.
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Identification of a novel partner of duox: EFP1, a thioredoxin-related protein.
Wang D, De Deken X, Milenkovic M, Song Y, Pirson I, Dumont JE, Miot F.
The Journal of Biological Chemistry 2005 Jan; 280(4):3096.
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Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family.
De Deken X, Wang D, Many MC, Costagliola S, Libert F, Vassart G, Dumont JE, Miot F.
The Journal of Biological Chemistry 2000 Jul; 275(30):23227.
Application:IHC-Fr, Human, Human paranodular thyroid tissues.
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Differential regulation of dual NADPH oxidases/peroxidases, Duox1 and Duox2, by Th1 and Th2 cytokines in respiratory tract epithelium.
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