INSIG1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of INSIG1.
Immunogen
A synthetic peptide corresponding to amino acids 1-100 of human INSIG1.
Host
Rabbit
Reactivity
Human
Specificity
This antibody is specific to Insig1 but not Insig2.
Form
Liquid
Recommend Usage
Western Blot (2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (30% glycerol, 0.09% sodium azide)
Storage Instruction
Store at -20°C or -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of INSIG1 in HepG2 lyaste using INSIG1 polyclonal antibody (Cat # PAB12411). -
Gene Info — INSIG1
Entrez GeneID
3638Protein Accession#
O15503Gene Name
INSIG1
Gene Alias
CL-6, MGC1405
Gene Description
insulin induced gene 1
Omim ID
602055Gene Ontology
HyperlinkGene Summary
Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory element-binding protein (SREBP)-mediated signaling pathways. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq
Other Designations
INSIG-1 membrane protein
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Interactome
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Disease
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Publication Reference
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Sex differences in hepatic regulation of cholesterol homeostasis.
De Marinis E, Martini C, Trentalance A, Pallottini V.
The Journal of Endocrinology 2008 Sep; 198(3):635.
Application:WB-Ti, Rat, Rat liver.
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Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake.
Gong Y, Lee JN, Lee PC, Goldstein JL, Brown MS, Ye J.
Cell Metabolism 2006 Jan; 3(1):15.
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Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins.
Engelking LJ, Liang G, Hammer RE, Takaishi K, Kuriyama H, Evers BM, Li WP, Horton JD, Goldstein JL, Brown MS.
The Journal of Clinical Investigation 2005 Sep; 115(9):2489.
Application:WB-Ti, Mouse, Liver.
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Sex differences in hepatic regulation of cholesterol homeostasis.
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