Cdkn2a polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of Cdkn2a in MEF lysate (25 ug) using Cdkn2a polyclonal antibody (Cat # PAB12146) (2 ug/mL).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of Cdkn2a.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to amino acids 50-150 of mouse Cdkn2a.
Host
Rabbit
Reactivity
Mouse
Specificity
On Western blot This antibody detects a band corresponding to p19ARF in mouse embryonic fibroblasts.
Form
Liquid
Recommend Usage
Western Blot (2 ug/mL)
Immunocytochemistry (1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris-citrate/phosphate buffer, pH 7.0-8.0 (0.09% sodium azide)
Storage Instruction
Store at 4°C for short term. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of Cdkn2a in MEF lysate (25 ug) using Cdkn2a polyclonal antibody (Cat # PAB12146) (2 ug/mL).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunocytochemistry
Enzyme-linked Immunoabsorbent Assay
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Gene Info — Cdkn2a
Entrez GeneID
12578Protein Accession#
Q64364;P51480Gene Name
Cdkn2a
Gene Alias
ARF-INK4a, Arf, INK4a-ARF, Ink4a/Arf, MTS1, Pctr1, p16, p16(INK4a), p16INK4a, p19<ARF>, p19ARF
Gene Description
cyclin-dependent kinase inhibitor 2A
Gene Ontology
HyperlinkGene Summary
inhibits CDK4)|cyclin-dependent kinase inhibitor protein|mitochondrial smARF
Other Designations
OTTMUSP00000008143|cyclin-dependent kinase inhibitor 2A (p16, inhibits CDK4)|cyclin-dependent kinase inhibitor protein|mitochondrial smARF
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Publication Reference
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mTORC1 promotes survival through translational control of Mcl-1.
Mills JR, Hippo Y, Robert F, Chen SM, Malina A, Lin CJ, Trojahn U, Wendel HG, Charest A, Bronson RT, Kogan SC, Nadon R, Housman DE, Lowe SW, Pelletier J.
PNAS 2008 Aug; 105(31):10853.
Application：WB-Ti, Mouse, Mouse lymphomas.
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Hepatitis B virus X protein via the p38MAPK pathway induces E2F1 release and ATR kinase activation mediating p53 apoptosis.
Wang WH, Hullinger RL, Andrisani OM.
The Journal of Biological Chemistry 2008 Jul; 283(37):25455.
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Increased DNA damage sensitivity and apoptosis in cells lacking the Snf5/Ini1 subunit of the SWI/SNF chromatin remodeling complex.
Klochendler-Yeivin A, Picarsky E, Yaniv M.
Molecular and Cellular Biology 2006 Apr; 26(7):2661.
Application：WB-Ce, Mouse, MEFs.
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Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice.
Baker DJ, Jeganathan KB, Malureanu L, Perez-Terzic C, Terzic A, van Deursen JM.
The Journal of Cell Biology 2006 Feb; 172(4):529.
Application：WB-Ce, Mouse, MEFs.
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mTORC1 promotes survival through translational control of Mcl-1.
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