Products

Western Blot

Western blot using THRA polyclonal antibody (Cat # PAB11276) shows detection of purified recombinant THRA (lane 1) and THRA present in a 293 cell lysate after transient transfection with THRA (lane 3).
No staining is evident in lysates from mock-transfected 293 cells (lane 2).
Endogenous THRA is not detected in mouse brain tissue lysate (lane 4).
Nuclear extracts may be required to detect endogenous THRA as the protein localizes within the nucleus.
The band at ~55 kDa, indicated by the arrowhead, corresponds to THRA.
Personal communication, S. Cheng and H. Ying, NCI, Bethesda, MD.

Immunoprecipitation

Enzyme-linked Immunoabsorbent Assay

Entrez GeneID

7067

Protein Accession#

NP_955366;P10827-2

Gene Name

THRA

Gene Alias

AR7, EAR7, ERB-T-1, ERBA, ERBA1, MGC000261, MGC43240, NR1A1, THRA1, THRA2, c-ERBA-1

Gene Description

thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)

Omim ID

190120

Gene Ontology

Hyperlink

Gene Summary

The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq

Other Designations

ERBA-related 7|OTTHUMP00000164470|avian erythroblastic leukemia viral (v-erb-a) oncogene homolog|thyroid hormone receptor alpha|thyroid hormone receptor, alpha|triiodothyronine receptor