NLRC4 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of NLRC4.
Immunogen
A synthetic peptide corresponding to amino acids 637-654 of human NLRC4.
Sequence
EEAPETYIPSRAVSLFFN
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In serum (0.05% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry (Frozen sections)
Immunoprecipitation
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Gene Info — NLRC4
Entrez GeneID
58484Gene Name
NLRC4
Gene Alias
CARD12, CLAN, CLAN1, CLANA, CLANB, CLANC, CLAND, CLR2.1, IPAF
Gene Description
NLR family, CARD domain containing 4
Omim ID
606831Gene Ontology
HyperlinkGene Summary
In C. elegans, Ced4 binds and activates Ced3, an apoptotic initiator caspase, via caspase-associated recruitment domains (CARDs). Human Ced4 homologs include APAF1 (MIM 602233), NOD1/CARD4 (MIM 605980), and NOD2/CARD15 (MIM 605956). These proteins have at least 1 N-terminal CARD domain followed by a centrally located nucleotide-binding domain (NBD or NACHT) and a C-terminal regulatory domain, found only in mammals, that contains either WD40 repeats or leucine-rich repeats (LRRs). CARD12 is a member of the Ced4 family and can induce apoptosis.[supplied by OMIM
Other Designations
ICE-protease activating factor|NOD-like receptor C4|caspase recruitment domain family, member 12|caspase recruitment domain protein 12|nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 4
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Interactome
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Disease
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Publication Reference
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Key component of inflammasome, NLRC4, was identified in the lesional epidermis of psoriatic patients.
Hiruma J, Harada K, Motoyama A, Okubo Y, Maeda T, Yamamoto M, Miyai M, Hibino T, Tsuboi R.
The Journal of Dermatology 2018 Aug; 45(8):971.
Application：IHC-P, Human, Skin, Psoriasis skin.
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Overexpression of NLRP3, NLRC4 and AIM2 inflammasomes and their priming-associated molecules (TLR2, TLR4, Dectin-1, Dectin-2 and NFκB) in Malassezia folliculitis.
Liang N, Yang YP, Li W, Wu YY, Zhang ZW, Luo Y, Fan YM.
Mycoses 2018 Feb; 61(2):111.
Application：IHC-P, Human, Human nskin.
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Key component of inflammasome, NLRC4, was identified in the lesional epidermis of psoriatic patients.
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