HDAC5 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of HDAC5 in 293 (lane 1) , Jurkat (lane 2) and NIH-3T3 (lane 3) cell lysate with HDAC5 polyclonal antibody (Cat # PAB0182) .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of HDAC5.
Immunogen
A synthetic peptide corresponding to amino acids 572-587 of human HDAC5.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS (0.05% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
ChIP
Western Blot (Cell lysate)
Western blot analysis of HDAC5 in 293 (lane 1) , Jurkat (lane 2) and NIH-3T3 (lane 3) cell lysate with HDAC5 polyclonal antibody (Cat # PAB0182) .Immunoprecipitation
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Gene Info — HDAC5
Entrez GeneID
10014Gene Name
HDAC5
Gene Alias
FLJ90614, HD5, NY-CO-9
Gene Description
histone deacetylase 5
Omim ID
605315Gene Ontology
HyperlinkGene Summary
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
antigen NY-CO-9
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Interactome
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Disease
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Publication Reference
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Epigenetic regulation of BDNF in the learned helplessness-induced animal model of depression.
Su C, Su C, Hsiao Y, Gean P.
Journal of Psychiatric Research 2016 May; 76:101.
Application：ChIP, WB, Mouse, Hippocampal tissues.
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Direct p53 transcriptional repression: in vivo analysis of CCAAT-containing G2/M promoters.
Imbriano C, Gurtner A, Cocchiarella F, Di Agostino S, Basile V, Gostissa M, Dobbelstein M, Del Sal G, Piaggio G, Mantovani R.
Molecular and Cellular Biology 2005 May; 25(9):3737.
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Epigenetic regulation of BDNF in the learned helplessness-induced animal model of depression.
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