INHBA (Human) Recombinant Protein

Catalog # P9947

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Size:100 ug
Price: USD $ 845.00
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Price: USD $ 479.00
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Contact Info
  • +1-909-264-1399
    +1-909-992-0619
    Toll Free : +1-877-853-6098
  • +1-909-992-3401
  • Specification

    Regulatory Status

    RUO grade

    Product Description

    Human INHBA recombinant protein expressed in Escherichia coli.

    Host

    Escherichia coli

    Theoretical MW (kDa)

    Calculated MW: 13.1

    Form

    Lyophilized

    Preparation Method

    Escherichia coli expression system

    Purity

    > 95% by SDS-PAGE

    Endotoxin Level

    < 0.1 EU/ug

    Activity

    The ED50 for this effect is < 10 ng/mL, measured by its ability to inhibit the proliferation of mouse MPC-11 cells. The specific activity of recombinant human Activin A is approximately > 1.0 x 103 IU/mg.

    Recommend Usage

    SDS-PAGE
    The optimal working dilution should be determined by the end user.

    Storage Buffer

    Lyophilized from PBS, pH 7.4.
    Reconstitute the lyophilized protein in sterile H2O to a concentration of at least 200 ug/mL and incubate the stock solution for at least 20 min to ensure sufficient redissolution. Please use the protein within one month after reconstitution.

    Storage Instruction

    Store at -20°C for 12 months in lyophilized state.
    After reconstitution with deionized water, store at -20 or -80°C for 1 month.
    Aliquot to avoid repeated freezing and thawing.

  • Applications

    Functional Study

    SDS-PAGE

  • Gene Info — INHBA

    Entrez GeneID

    3624

    Gene Name

    INHBA

    Gene Alias

    EDF, FRP

    Gene Description

    inhibin, beta A

    Omim ID

    147290

    Gene Ontology

    Hyperlink

    Gene Summary

    The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. Finally, it has been shown that the beta A subunit mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in the human genome. [provided by RefSeq

    Other Designations

    FSH-releasing protein|Inhibin, beta-1|erythroid differentiation factor|follicle-stimulating hormone-releasing protein|inhibin beta A|inhibin, beta A (activin A, activin AB alpha polypeptide)

  • Interactome
  • Pathway
  • Disease
Contact Info
  • +1-909-264-1399
    +1-909-992-0619
    Toll Free : +1-877-853-6098
  • +1-909-992-3401
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