IL17RB (Human) Recombinant Protein
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Specification
Product Description
Human IL17RB (Q9NRM6-1, Arg18-Per292) partial recombinant protein with His tag at C-Terminus expressed in HEK293 cells.
Sequence
Arg18-Per292
Host
Human
Theoretical MW (kDa)
31.4
Form
Lyophilized
Preparation Method
Mammalian cell (HEK293) expression system
Purity
> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Endotoxin Level
< 1 EU per 1 ug of protein (determined by LAL method)
Activity
The EC50 was 4.4 ng/mL, messured by ELISA at 0.2 ug/mL. The affinity constant of 0.81 nM as determined in SPR assay (Biacore T200).
Quality Control Testing
SEC-HPLC and Tris-Bis PAGE
SEC-HPLC
The purity of Human IL-17RB is greater than 95% as determined by SEC-HPLC.
Tris-Bis PAGE
Human IL-17RB on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
Recommend Usage
Biological Activity
ELISA
SDS-PAGE
SPR
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from sterile distilled Water is > 100 ug/mL
Storage Instruction
Store at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing.Note
Result of bioactivity analysis
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Applications
Enzyme-linked Immunoabsorbent Assay
Immobilized Human IL-17RB, His Tag at 0.2 ug/mL (100 uL/well) on the plate. Dose response curve for Anti-IL-17RB Antibody, hFc Tag with the EC50 of 4.4 ng/mL determined by ELISA (QC Test).Functional Study
SDS-PAGE
Surface Plasmon Resonance
Human IL-17RB, His Tag immobilized on CM5 Chip can bind Human IL-25, His Tag with an affinity constant of 0.81 nM as determined in SPR assay (Biacore T200). -
Gene Info — IL17RB
Entrez GeneID
55540Protein Accession#
Q9NRM6-1Gene Name
IL17RB
Gene Alias
CRL4, EVI27, IL17BR, IL17RH1, MGC5245
Gene Description
interleukin 17 receptor B
Omim ID
605458Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E, but does not bind to IL17 and IL17C. This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor. [provided by RefSeq
Other Designations
IL-17B receptor|cytokine receptor CRL4|interleukin 17 receptor homolog 1|interleukin 17B receptor
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