ICOS (Human) Recombinant Protein
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More Files
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Surface Plasmon Resonance
Human ICOS, hFc Tag (Q50A) captured on CM5 Chip via Protein A can bind Human B7-H2, His Tag with an affinity constant of 41.98 nM as determined in SPR assay (Biacore T200).
SEC-HPLC
The purity of Human ICOS (Q50A) is greater than 95% as determined by SEC-HPLC.
Tris-Bis PAGE
Human ICOS (Q50A) on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
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Specification
Product Description
Human ICOSB (Q9Y6W8-1, Glu21-Phe141) partial recombinant protein with hFc tag at C-terminus expressed in HEK293 cells.
Sequence
Glu21-Phe141
Host
Human
Theoretical MW (kDa)
40.45
Form
Lyophilized
Preparation Method
Mammalian cell (HEK293) expression system
Quality Control Testing
SEC-HPLC and Tris-Bis PAGE
SEC-HPLC
The purity of Human ICOS (Q50A) is greater than 95% as determined by SEC-HPLC.
Tris-Bis PAGE
Human ICOS (Q50A) on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
Recommend Usage
Biological Activity
SPR
SDS-PAGE
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from sterile distilled Water is > 100 ug/mL
Storage Instruction
Store at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing.Note
Result of bioactivity analysis
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Applications
Functional Study
SDS-PAGE
Surface Plasmon Resonance
Human ICOS, hFc Tag (Q50A) captured on CM5 Chip via Protein A can bind Human B7-H2, His Tag with an affinity constant of 41.98 nM as determined in SPR assay (Biacore T200). -
Gene Info — ICOS
Entrez GeneID
29851Protein Accession#
Q9Y6W8-1Gene Name
ICOS
Gene Alias
AILIM, CD278, MGC39850
Gene Description
inducible T-cell co-stimulator
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. [provided by RefSeq
Other Designations
activation-inducible lymphocyte immunomediatory molecule|inducible costimulator
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Interactome
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Pathway
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Disease
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